Alnespiron

Alnespiron (S-20,499) je selektivni pun agonist 5-HT_1A receptora iz azapironske hemijske klase.^[1]^[2]^[3] On ima antidepresivne i anksiolitičke efekte.^[1]

Reference

^ ^а ^б Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J (1992). „Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.”. Neuroreport.. 3 (1): 84—86. PMID 1351756. doi:10.1097/00001756-199201000-00022.
^ Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J (1992). „5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.”. Psychopharmacology (Berl).. 108 (1-2): 47—50. PMID 1357709. doi:10.1007/BF02245284.
^ Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G (2003). „In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.”. Eur J Pharmacol.. 459 (1): 17—26. PMID 12505530. doi:10.1016/S0014-2999(02)02814-5.