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functional-annotation

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An epigenome-wide association study (EWAS) pipeline profiling DNA methylation (5mC) dynamics across post-mortem Alzheimer's brain regions. Investigates cell-type-specific differential methylation and chromatin accessibility correlations, utilizing OLS with robust standard errors and machine learning biomarker panel classification.

  • Updated May 23, 2026
  • Python

Bakta and Prokka call the same 87,859 CDS regions in 25 complete bacterial genomes, then give 51.7% of them different product names. Both wrap Prodigal, so they agree on gene boundaries and diverge on function. Grouped-by-genome ML shows the disagreement tracks database coverage, not sequence.

  • Updated Aug 23, 2026
  • Python

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