pbpk

Predicting tissue distribution of highly lipophilic compounds

A copycat of Raja Brawijaya 2016

R client for PopGen web service

Create diagrams with ggplot.

The physiologically-based whole-body model of the glucose-insulin-glucagon regulatory system

Whole-body PBPK model of theophylline as CYP1A2 DDI victim drug

Exemplary Protein PBPK Models

Modeling of published clinical Rifampicin-Theophylline-DDI studies for model evaluation

Modeling of published clinical Fluvoxamine-Theophylline-DDI studies for model evaluation

A multiscale QSP model of IFN-alpha induced activation of the JAK/STAT pathway in human liver cells (Kalra et al., 2019)

Whole-body PBPK model of gemfibrozil as CYP2C8 and OATP1B1 DDI perpetrator drug

Whole-body PBPK model of pioglitazone as CYP2C8 DDI victim drug

Modeling of published clinical gemfibrozil-repaglinide-DDI studies for model evaluation

Modeling of published clinical gemfibrozil-pioglitazone-DDI studies for model evaluation

Modeling of published clinical itraconazole-repaglinide-DDI studies for model evaluation

Modeling of published clinical itraconazole-pioglitazone-DDI studies for model evaluation

Modeling of published clinical gemfibrozil-itraconazole-repaglinide-DDI studies for model evaluation

Modeling of published clinical gemfibrozil-itraconazole-pioglitazone-DDI studies for model evaluation

Modeling of published clinical rifampicin-repaglinide-DDI studies for model evaluation

Modeling of published clinical rifampicin-pioglitazone-DDI studies for model evaluation