Amoxicillin-Model

Whole-body PBPK model of intravenously administered amoxicillin in adults, pregnant women and postpartum women

Within this repository, we distribute a whole-body PBPK models of intravenously administered amoxicillin in adults, pregnant women and postpartum women. Details on model building and evaluation have been published previously [1].

This repository contains a PK-Sim^® file with amoxicillin simulations in adults and another PK-Sim^® file with simulations in pregnant women and postpartum women.

The postpartum anatomy and physiology is not integrated in the PK-Sim^® database. Therefore, this repository also contains the MoBi^® file with the postpartum model structure (please note that this model is not correctly parameterized in terms of the postpartum anatomy and physiology) and a csv file with the anatomical and physiological parameters of 2000 postpartum individuals. Both files can used for importing and running a postpartum population simulation in PK-Sim^®.

PK-Sim Version 8.0

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc.) is expected to follow the Open Systems Pharmacology code of conduct.

The model is distributed under the GPLv2 License.

[1] Dallmann, A., Himstedt, A., Solodenko, J. et al. Integration of physiological changes during the postpartum period into a PBPK framework and prediction of amoxicillin disposition before and shortly after delivery. J Pharmacokinet Pharmacodyn (2020).