Isonocardicin synthase
| Isonocardicin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.38 | ||||||||
| CAS no. | 118246-74-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Isonocardicin synthase (EC 2.5.1.38) is an enzyme that catalyzes a chemical reaction which transfers the 3-amino-3-carboxypropyl group from its coenzyme, S-adenosyl methionine (SAM), giving 5'-methylthioadenosine as a byproduct.[1][2] The enzyme from Nocardia uniformis can act on several natural beta lactams of the nocardicin type but the main reaction in the biosynthetic pathway leading to nocardicin A converts nocardicin G to isonocardicin C:[3]
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase. This enzyme is also called nocardicin aminocarboxypropyltransferase.[4]
References
[edit]- ↑ Wilson, Brenda A.; Bantia, Shanta.; Salituro, Gino M.; Reeve, Anne M.; Townsend, Craig A. (1988). "Cell-free biosynthesis of nocardicin a from nocardicin e and S-adenosylmethionine". Journal of the American Chemical Society. 110 (24): 8238–8239. doi:10.1021/ja00232a047.
- ↑ Reeve, Anne M.; Breazeale, Steven D.; Townsend, Craig A. (1998). "Purification, Characterization, and Cloning of an S-Adenosylmethionine-dependent 3-Amino-3-carboxypropyltransferase in Nocardicin Biosynthesis". Journal of Biological Chemistry. 273 (46): 30695–30703. doi:10.1074/jbc.273.46.30695. PMID 9804844.
- ↑ Kelly, Wendy L.; Townsend, Craig A. (2005). "Mutational Analysis of nocK and nocL in the Nocardicin a Producer Nocardia uniformis". Journal of Bacteriology. 187 (2): 739–746. doi:10.1128/JB.187.2.739-746.2005. PMC 543527. PMID 15629944.
- ↑ Enzyme 2.5.1.38 at KEGG Pathway Database.
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