Cardiovascular diseases articles from across Nature Portfolio

Proteomic profiling of 149 explanted human hearts shows that, in end-stage heart failure, protein profiles converge across etiologies. Proteome profiles indicate that molecular subtyping, rather than clinical phenotyping, may better capture patient heterogeneity.

Aging is a major cardiovascular risk factor, but the mechanisms that underlie cardiac inflammaging remain unclear. A study now shows that lymphatic rarefaction is an early determinant of cardiac aging and identifies a VEGF-C– IL-33 signaling axis that regulates lymphatic homeostasis.

The administration of Bacteroides uniformis in mice can mitigate atherosclerosis via pentadecanoic acid, which directly inhibits HMG-CoA reductase to promote hepatic cholesterol clearance.

By integrating proteomics, genetics and imaging, this study identifies candidate blood biomarkers of pulmonary hypertension, implicates NOTCH3 in disease development, and defines distinct biological subtypes of individuals at risk for this condition.

Proteomic profiling of 149 explanted human hearts shows that, in end-stage heart failure, protein profiles converge across etiologies. Proteome profiles indicate that molecular subtyping, rather than clinical phenotyping, may better capture patient heterogeneity.

Data from the ACACIA-HCM trial show that treatment with the myosin inhibitor aficamten improves exercise capacity and patient-reported health status compared with placebo in patients with non-obstructive hypertrophic cardiomyopathy.

In patients with symptomatic severe tricuspid regurgitation, transcatheter tricuspid repair in addition to medical therapy not only improves quality of life compared with medical therapy alone, but also significantly reduces the risk of all-cause death and hospitalization for heart failure, according to the results from the investigator-initiated TRIC-I-HF-DZHK24 trial.