Folic Acid

Modify Date: 2026-06-30 14:40:07

Folic Acid Structure
Folic Acid structure
Common Name Folic Acid
CAS Number 59-30-3 Molecular Weight 441.397
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C19H19N7O6 Melting Point 250 °C
MSDS Chinese USA Flash Point N/A

 Use of Folic Acid


Folic acid(Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name folic acid
Synonym More Synonyms

 Folic Acid Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Folic acid(Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
Related Catalog

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.6±0.1 g/cm3
Melting Point 250 °C
Molecular Formula C19H19N7O6
Molecular Weight 441.397
Exact Mass 441.139679
PSA 213.28000
LogP -2.48
Index of Refraction 1.755
InChIKey OVBPIULPVIDEAO-LBPRGKRZSA-N
SMILES Nc1nc2ncc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)nc2c(=O)[nH]1
Storage condition 2~8°C
Water Solubility 1.6 mg/L (25 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LP5425000
CHEMICAL NAME :
Folic acid
CAS REGISTRY NUMBER :
59-30-3
LAST UPDATED :
199806
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C19-H19-N7-O6
MOLECULAR WEIGHT :
441.45
WISWESSER LINE NOTATION :
T66 BN DN GN JNJ CZ EQ H1MR DVMYVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Behavioral - coma
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes Blood - changes in spleen
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
282 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
150 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,136,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1051 No. of Facilities: 220 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 11106 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1051 No. of Facilities: 2823 (estimated) No. of Industries: 11 No. of Occupations: 40 No. of Employees: 60281 (estimated) No. of Female Employees: 29903 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R33;R62;R68
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS LP5425000
HS Code 2936290090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2936290090

 Articles306

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.

BMC Genomics 16 , 151, (2015)

Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other euka...

Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations.

J. Nutr. 145(1) , 79-86, (2015)

Folates are essential cofactors in metabolic pathways that facilitate biological methylation and nucleotide synthesis, and therefore have widespread effects on health and diseases. Although obesity is...

Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application.

Int. J. Pharm. 484(1-2) , 276-82, (2015)

Stabilization of graphene oxide (GO) in physiological solution is performed using hydroxyethyl cellulose (HEC) to make the resultant nanohybrid suitable for targeted drug delivery purposes. Short and ...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

VM/PGA
Folbal
folic
FOLSAN
Folic acid
Folate
N-[p-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic Acid
EINECS 200-419-0
Folan
N-(p-[(2-Amino-4-hydroxypyrimido[4,5-b]pyrazin-6-yl)methylamino]benzoyl)glutamic Acid
pteroic acid-glutamate
Pteroyglutamic acid
Folsav
PGA
MFCD00079305
PTEGLU
N-(4-{[(2-Amino-4-oxo-4,8-dihydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
2-[(4-{[(2-Amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioic acid
N-(4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)glutamic acid
Aspol
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
N-(4-{[(2-Amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)glutamic acid
Folicacidhydrate

 Folic Acid | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the storage conditions for folic acid?
A: Storage conditions for folic acid: 2~8°C.
Q: What is the LogP of folic acid?
A: LogP of folic acid is -2.48.
Q: What are the upstream materials of folic acid?
A: Related upstream materials(CAS) of folic acid: 58-05-9;10016-20-3;65165-92-6;497-15-4;4271-30-1.
Q: What are the downstream products of folic acid?
A: Related downstream products(CAS) of folic acid: 31690-09-2;4230-33-5;712-30-1;54-62-6;37793-53-6;4271-30-1;948-60-7;150-13-0;4033-27-6.
Q: What is the InChIKey of folic acid?
A: InChIKey of folic acid is OVBPIULPVIDEAO-LBPRGKRZSA-N.
Q: What is the CAS number of folic acid?
A: CAS number of folic acid is 59-30-3.
Q: What is the melting point of folic acid?
A: Melting point of folic acid is 250 °C.
Q: What is the polar surface area (PSA) of folic acid?
A: Polar surface area (PSA) of folic acid is 213.28000.
Q: What is the molecular formula of folic acid?
A: Molecular formula of folic acid is C19H19N7O6.
Q: What is the SMILES notation of folic acid?
A: SMILES notation of folic acid is Nc1nc2ncc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)nc2c(=O)[nH]1.

 Folic Acidfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Huangshi Healthday Pharmaceutical Technology Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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