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중증 화상 (Major Thermal Burn Injury) — QSP 모델 참고문헌

References for the Major Thermal Burn Injury QSP model

출처에 대하여 (provenance). 아래 352편은 NCBI E-utilities(esearch + esummary)로 각 절의 주제에 해당하는 검색어를 실제로 질의해 반환된 레코드만 옮긴 것입니다. 제목·저자·저널·연도·PMID는 모두 NCBI가 돌려준 값 그대로이며, 기억이나 추정으로 채워 넣은 항목은 하나도 없습니다. 검색 시점은 2026-08입니다.

모델의 정량적 주장이 어느 문헌에 걸려 있는지는 맨 끝 부록 A에 표로 정리했습니다.

이 모델이 문헌에서 가져온 숫자 (Calibration targets)

# 보정 목표 문헌값 모델값 근거 절
1 UO 적정 파클랜드의 24시간 수액량 5.2–6.7 mL/kg/%TBSA 5.97 C
2 in:out 비 (투여량 ÷ 파클랜드 처방량) 1.2–1.6 1.49 C
3 복강내 고혈압 역치 약 250 mL/kg/24 h 269 mL/kg → IAP 14.2 mmHg D
4 혈장량 최저점 기저의 60–80 % 62 % B
5 24시간 혈장 교질삼투압 10–16 mmHg (기저 약 26) 13.0 B
6 최대 체중 증가 +15~30 % +20 % C·D
7 최대 REE 예측치의 120–180 % 157 % (45 %TBSA) F
8 REE의 지속 창상 폐쇄 후 수개월~수년 60일째 135 % F
9 제지방량 변화 (14일, 무투약) 약 −9 % −7.1 % F·G
10 제지방량 변화 (14일, 프로프라놀롤) 약 +9 % 아래 본문 참조 G
11 고용량 아스코르브산의 수액 절감 −45 % −36 % E
12 알부민의 수액 절감 −20~−40 % −5 % (8시간 시작) / −38 % (0시간) C
13 침습성 창상 감염 역치 10⁵ CFU/g 초과 모델 BTHRESH = 5 log₁₀ K
14 개정 Baux 점수와의 일치 LD50 약 110 8개 환자 평균오차 3.2 %p A
15 화상 환자의 증가된 신클리어런스 CrCl 130 mL/min 초과 flow phase에서 ×1.55 L

모델이 문헌과 어긋나는 곳은 지우지 않고 그대로 두었습니다. 가장 노출된 예측은 12번입니다. 모델은 8시간에 시작한 알부민이 수액량을 거의 줄이지 못한다고 말하며, 그 이유를 기전으로 제시합니다 — 파클랜드의 전반 8시간 집중 투여 형태에서는 8시간 시점에 이미 교질삼투압 희석의 대부분이 끝나 있기 때문입니다. 같은 콜로이드 분율을 0시간에 시작하면 −38 %입니다. 이것은 검증 가능한 주장이며, 시험에서 시작 시점이 그만큼 중요하지 않다면 이 구조가 틀린 것입니다. 11번(아스코르브산)이 Tanaka의 값을 잘 재현하는 것도 승리가 아니라 문제입니다 — 이후 어떤 시험도 그 결과를 재현하지 못했으므로, 모델은 사실이 아닐 수 있는 결과에 맞춰져 있는 셈입니다.

A. 역학·중증도·예후 (Epidemiology, severity, prognosis)

21편

  • Tomaka P et al. Prognostic Value of Mortality Scoring Systems in Patients With Severe Burns: Identifying Key Predictors of Mortality and Comparative Analysis Between Survivors and Non-Survivors Med Sci Monit 32:e951713 (2026). PMID 42458800
  • Goder N et al. Recalibrating the revised Baux score: Admission and 48-hour landmark survival models in contemporary older adult patients with burn injury Burns 52:108141 (2026). PMID 42407276
  • Belayneh ES et al. Accuracy of the revised Baux score for predicting in-hospital mortality of patients with burns: A retrospective cohort study from Ethiopia J Plast Reconstr Aesthet Surg 119:375-381 (2026). PMID 42399141
  • Ren H et al. Interpretative machine learning for predicting 60-day mortality in burn patients with suspected infection World J Emerg Med 17:244-249 (2026). PMID 42199764
  • Nehila T et al. Revised Baux Score Identifies a New Risk Factor for Mortality: History of Diabetes Adv Skin Wound Care 39:304-307 (2026). PMID 42155058
  • Alshdowh H et al. Burn Injuries in Jordan: A 5-Year Retrospective Analysis of Presentation, Management and Hospital Mortality Int Wound J 23:e70839 (2026). PMID 41601206
  • Schmitt A et al. Epidemiology and prognostic factors in older adults with severe burns (≥10% TBSA): A 13-year retrospective study from a French national burn center Burns 52:108104 (2026). PMID 42308703
  • Dean YE et al. Predictors of Mortality and Outcomes in Older Adult Burn Patient Subgroups: A Comparative Meta-analysis of Age, Burn Severity, and Intervention Strategies Plast Reconstr Surg Glob Open 14:e7708 (2026). PMID 42164960
  • Zhang L et al. Early blood urea nitrogen-albumin ratio as a prognostic marker in severe burn patients: A retrospective clinical study Burns 52:107871 (2026). PMID 41632997
  • Ahn J et al. Artificial intelligence for outcome prediction in burn care: A scoping review Burns 52:108121 (2026). PMID 42407287
  • Danielski LG et al. Performance of Sepsis-3 criteria in burn patients: A multicenter real-world study Burns 52:108073 (2026). PMID 42302549
  • Baddam S et al. Systemic Inflammatory Response Syndrome ** (2026). PMID 31613449
  • Wu R et al. Early versus delayed laparoscopic cholecystectomy for gallbladder perforation J Trauma Acute Care Surg 98:642-648 (2025). PMID 40122846
  • Heard J et al. Burn Injury Severity in Adults: Proposed Definitions Based on the National Burn Research Dataset J Burn Care Res 46:438-449 (2025). PMID 39320264
  • Rhee C et al. Improving Sepsis Outcomes in the Era of Pay-for-Performance and Electronic Quality Measures: A Joint IDSA/ACEP/PIDS/SHEA/SHM/SIDP Position Paper Clin Infect Dis 78:505-513 (2024). PMID 37831591
  • López-Sánchez I et al. Temporal trends in epidemiology and patient characteristics of 36 cancers: a protocol for a multinational population-based cohort study using OMOP-standardised databases to investigate CANcer (OMOPCAN) BMJ Open 16:e119069 (2026). PMID 42481199
  • Patel P et al. Epidemiology and Outcomes of Burn Injuries: A Retrospective Study at a Tertiary Care Center Ann Plast Surg (2026). PMID 42295771
  • Miller CL et al. The tale of two states: mortality outcomes and burn severity among in-state versus out-of-state burn victims treated in the Texas Panhandle Proc (Bayl Univ Med Cent) 39:650-656 (2026). PMID 42269065
  • Daniels M et al. The influence of burn injury timing on survival in patients with severe burns Injury 57:113302 (2026). PMID 42054930
  • Watanabe T et al. The association between hospital volume and in-hospital mortality in severe burn patients: A nationwide study using the Japanese Burn Registry Burns 52:107959 (2026). PMID 41950740
  • Cueva-Ramírez JE et al. Epidemiological Characteristics and Prognostic Factors for Mortality in Severe Burns: A 32-Year Analysis (1993-2024) From a National Referral Center in the Dominican Republic World J Surg 50:1159-1168 (2026). PMID 41931542

B. 화상 부종의 미세혈관 기전 (Microvascular mechanism of burn oedema)

24편

  • Ferrara JJ et al. Alpha-trinositol reduces edema formation at the site of scald injury Surgery 123:36-45 (1998). PMID 9457221
  • Ferrara JJ et al. Burn edema reduction by methysergide is not due to control of regional vasodilation J Surg Res 61:11-6 (1996). PMID 8769935
  • Ferrara JJ et al. Effects of methysergide administration on edema formation at the site of scald J Appl Physiol (1985) 78:191-7 (1995). PMID 7713811
  • Ferrara JJ et al. Effects of pentafraction administration on microvascular permeability alterations induced by graded thermal injury Surgery 115:182-9 (1994). PMID 7508639
  • Dyess DL et al. Effects of hypertonic saline and dextran 70 resuscitation on microvascular permeability after burn Am J Physiol 262:H1832-7 (1992). PMID 1377878
  • Isago T et al. Analysis of pulmonary microvascular permeability after smoke inhalation J Appl Physiol (1985) 71:1403-8 (1991). PMID 1757363
  • Lund T et al. Mechanisms behind increased dermal imbibition pressure in acute burn edema Am J Physiol 256:H940-8 (1989). PMID 2705564
  • Lund T et al. Acute postburn edema: role of strongly negative interstitial fluid pressure Am J Physiol 255:H1069-74 (1988). PMID 3189570
  • Tanaka H et al. High dose vitamin C counteracts the negative interstitial fluid hydrostatic pressure and early edema generation in thermally injured rats Burns 25:569-74 (1999). PMID 10563680
  • Bert J et al. Fluid resuscitation following a burn injury: implications of a mathematical model of microvascular exchange Burns 23:93-105 (1997). PMID 9177874
  • Lund T et al. Alpha-Trinositol inhibits edema generation and albumin extravasation in thermally injured skin J Trauma 36:761-5 (1994). PMID 8014994
  • Lund T et al. Pathogenesis of edema formation in burn injuries World J Surg 16:2-9 (1992). PMID 1290261
  • Rehberg S et al. Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury Crit Care Med 41:e439-46 (2013). PMID 24107637
  • Sakurai H et al. Inhibition of lung permeability changes after burn and smoke inhalation by an anti-interleukin-8 antibody in sheep Surg Today 39:399-406 (2009). PMID 19408077
  • Maybauer DM et al. Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity Biochem Biophys Res Commun 377:786-91 (2008). PMID 18951875
  • Jonkam CC et al. Effects of the bradykinin B2 receptor antagonist icatibant on microvascular permeability after thermal injury in sheep Shock 28:704-9 (2007). PMID 17607158
  • Enkhbaatar P et al. Effect of inhaled nitric oxide on pulmonary vascular hyperpermeability in sheep following smoke inhalation Burns 31:1013-9 (2005). PMID 16288960
  • Katahira J et al. Role of anti-L-selectin antibody in burn and smoke inhalation injury in sheep Am J Physiol Lung Cell Mol Physiol 283:L1043-50 (2002). PMID 12376357
  • Hundeshagen G et al. Closed-Loop- and Decision-Assist-Guided Fluid Therapy of Human Hemorrhage Crit Care Med 45:e1068-e1074 (2017). PMID 28682837
  • Cartotto R et al. Colloids in Acute Burn Resuscitation Crit Care Clin 32:507-23 (2016). PMID 27600123
  • Huang W et al. [Effects on vascular permeability with different fluid resuscitation regimens during burn stage in swines] Zhonghua Yi Xue Za Zhi 95:943-6 (2015). PMID 26081060
  • Cartotto R Fluid resuscitation of the thermally injured patient Clin Plast Surg 36:569-81 (2009). PMID 19793552
  • Kinsky MP et al. Resuscitation of severe thermal injury with hypertonic saline dextran: effects on peripheral and visceral edema in sheep J Trauma 49:844-53 (2000). PMID 11086774
  • Guha SC et al. Burn resuscitation: crystalloid versus colloid versus hypertonic saline hyperoncotic colloid in sheep Crit Care Med 24:1849-57 (1996). PMID 8917036

C. 소생술 공식과 수액 크립 (Resuscitation formulae and fluid creep)

35편

  • Alotaibi AM et al. The impact of resuscitation strategies on burn patient outcomes: Parkland vs. modified Brooke's Int J Burns Trauma 15:220-226 (2025). PMID 41278384
  • Schutzman LM et al. Metabolomic Assessment of Low- Versus High-Volume Resuscitation in a Combined Porcine Model of Severe Burn and Traumatic Brain Injury Shock 65:218-225 (2026). PMID 40997256
  • Dilken O et al. Microcirculatory depth of focus measurement shows reduction of tissue edema by albumin resuscitation in burn patients J Intensive Med 5:58-63 (2025). PMID 39872843
  • Vasileiadis V et al. Fluid and burns in children: What we know and what we do not know-a retrospective analysis of the German Burn Registry from 2015 to 2022 Eur J Pediatr 183:5479-5488 (2024). PMID 39436457
  • Peters J et al. Using a Fluid Resuscitation Algorithm to Reduce the Incidence of Abdominal Compartment Syndrome in the Burn Intensive Care Unit Crit Care Nurse 43:58-66 (2023). PMID 38035617
  • Oboli VN et al. EMS Burn Rule of Tens ** (2026). PMID 37983357
  • Saffle JR Fluid Creep and Over-resuscitation Crit Care Clin 32:587-98 (2016). PMID 27600130
  • Faraklas I et al. Review of a fluid resuscitation protocol: "fluid creep" is not due to nursing error J Burn Care Res 33:74-83 (2012). PMID 22240507
  • Lawrence A et al. Colloid administration normalizes resuscitation ratio and ameliorates "fluid creep" J Burn Care Res 31:40-7 (2010). PMID 20061836
  • Saffle JI The phenomenon of "fluid creep" in acute burn resuscitation J Burn Care Res 28:382-95 (2007). PMID 17438489
  • Friedrich JB et al. Is supra-Baxter resuscitation in burn patients a new phenomenon? Burns 30:464-6 (2004). PMID 15225912
  • Engrav LH et al. A biopsy of the use of the Baxter formula to resuscitate burns or do we do it like Charlie did it? J Burn Care Rehabil 21:91-5 (2000). PMID 10752739
  • Datchinamourthy T et al. Comparison of effect of Ringer's lactate and isotonic bicarbonate combination therapy with Ringer's lactate alone in early fluid resuscitation of burns patients - A randomised controlled trial Burns 51:107752 (2025). PMID 41197195
  • Liu XY et al. Preliminary exploration of efficacy assessment and optimal concentration of teprenone oral rehydration solution for the early management of post-burn shock Burns 51:107615 (2025). PMID 40651116
  • O'Neill R et al. Inhalational Injury Secondary to House Fire J Educ Teach Emerg Med 8:S49-S79 (2023). PMID 37969154
  • Dahl R et al. Regional Burn Review: Neither Parkland Nor Brooke Formulas Reach 85% Accuracy Mark for Burn Resuscitation J Burn Care Res 44:1452-1459 (2023). PMID 37010149
  • Popowicz P et al. Burn Fluid Resuscitation ** (2026). PMID 30480960
  • Hassan AM et al. Development of an open-source, protocol-adherent platform for real-time burn fluid resuscitation management J Plast Reconstr Aesthet Surg 116:312-314 (2026). PMID 41813514
  • Kahn SA et al. Challenging Legacy Burn Resuscitation Paradigms with Fluid Restriction and Early Plasma J Am Coll Surg 240:339-347 (2025). PMID 39902941
  • Chiao HY et al. Goal-Directed Fluid Resuscitation Protocol Based on Arterial Waveform Analysis of Major Burn Patients in a Mass Burn Casualty Ann Plast Surg 80:S21-S25 (2018). PMID 29389698
  • Huang M et al. A comparison of two different fluid resuscitation management protocols for pediatric burn patients: A retrospective study Burns 44:82-89 (2018). PMID 29229195
  • Cancio LC et al. Protocolized Resuscitation of Burn Patients Crit Care Clin 32:599-610 (2016). PMID 27600131
  • Sánchez-Sánchez M et al. First resuscitation of critical burn patients: progresses and problems Med Intensiva 40:118-24 (2016). PMID 26873418
  • Wardhana A et al. The impact of Albumin Administration on Mortality and Resuscitation Volume in Burn Resuscitation: A Systematic Review and Meta-Analysis Bull Emerg Trauma 13:203-214 (2025). PMID 41268471
  • Lewis SR et al. Colloids versus crystalloids for fluid resuscitation in critically ill people Cochrane Database Syst Rev 8:CD000567 (2018). PMID 30073665
  • Eljaiek R et al. Albumin administration for fluid resuscitation in burn patients: A systematic review and meta-analysis Burns 43:17-24 (2017). PMID 27613476
  • Perel P et al. Colloids versus crystalloids for fluid resuscitation in critically ill patients Cochrane Database Syst Rev:CD000567 (2013). PMID 23450531
  • Perel P et al. Colloids versus crystalloids for fluid resuscitation in critically ill patients Cochrane Database Syst Rev:CD000567 (2012). PMID 22696320
  • Roberts I et al. Human albumin solution for resuscitation and volume expansion in critically ill patients Cochrane Database Syst Rev 2011:CD001208 (2011). PMID 22071799
  • Greenhalgh DG et al. A Prospective, Randomized, Multicenter Trial Comparing Lactated Ringer's Alone or With 5% Albumin for Resuscitation of Large Burns The Acute Burn ResUscitation Multicenter Prospective Trial 2 (ABRUPT2) Ann Surg (2026). PMID 42144653
  • Tang F et al. Early supplemental parenteral nutrition shortens ventilation and intensive care unit stay in ICU patients aged ≥60 Years requiring mechanical ventilation: A randomized controlled trial Clin Nutr ESPEN 72:102933 (2026). PMID 41565072
  • Abdelmotaal AM et al. Effect of Hydroxyethyl starch (HES) versus 5% albumin solution on intra-abdominal pressure in severe burn patients: A prospective randomized clinical trial Burns 50:197-203 (2024). PMID 37833147
  • Greenhalgh DG et al. Burn Resuscitation Practices in North America: Results of the Acute Burn ResUscitation Multicenter Prospective Trial (ABRUPT) Ann Surg 277:512-519 (2023). PMID 34417368
  • Palmieri TL Transfusion and Infections in the Burn Patient Surg Infect (Larchmt) 22:49-53 (2021). PMID 32559401
  • Li B et al. Resuscitation Fluids in Septic Shock: A Network Meta-Analysis of Randomized Controlled Trials Shock 53:679-685 (2020). PMID 31693630

D. 소생술 합병증 (Resuscitation morbidity)

14편

  • Wiktor AJ et al. Safety and Efficacy of an Early Low-Dose Fresh Frozen Plasma Infusion in Burn Resuscitation J Burn Care Res 47:807-816 (2026). PMID 41466517
  • Zhou D et al. Lessons from the similarities and differences in fluid resuscitation between burns and sepsis: a bibliometric analysis Front Med (Lausanne) 12:1561619 (2025). PMID 40103790
  • Kenney CL et al. Neurologic Complications Associated With Burn Injury and Resuscitation J Surg Res 304:36-40 (2024). PMID 39515023
  • Halalmeh DR et al. The role of a specialized urethral catheter in early detection of intra-abdominal hypertension: a case report J Surg Case Rep 2024:rjae653 (2024). PMID 39421340
  • Curry D et al. Revision of an Adult Burn Center's Resuscitation Guideline Leads to Lower Resuscitation Requirements J Burn Care Res 45:1499-1504 (2024). PMID 38824401
  • Payne ML et al. Effect of Dexmedetomidine on Fluid Resuscitation in Burn-Injured Patients J Burn Care Res 45:1257-1263 (2024). PMID 38459902
  • Arcieri TR et al. Intraabdominal hypertension and abdominal compartment syndrome: What you need to know J Trauma Acute Care Surg 99:504-513 (2025). PMID 40189748
  • Tayebi S et al. In Vitro Validation of a Novel Continuous Intra-Abdominal Pressure Measurement System (TraumaGuard) J Clin Med 12 (2023). PMID 37834904
  • Grünherz L et al. Enzymatic debridement for circumferential deep burns: the role of surgical escharotomy Burns 49:304-309 (2023). PMID 36604280
  • Keyloun JW et al. An unusual presentation of inhalation injury in a patient with high voltage electrical injury: A case report Int J Surg Case Rep 77:357-361 (2020). PMID 33217653
  • Zhang IY et al. Validation of a low-cost simulation strategy for burn escharotomy training Injury 51:2059-2065 (2020). PMID 32564962
  • Mataro I et al. Releasing Burn-Induced Compartment Syndrome by Enzymatic Escharotomy-Debridement: A Case Study J Burn Care Res 41:1097-1103 (2020). PMID 32232328
  • Delgado-Miguel C et al. Iatrogenic Compartment Syndrome Secondary to Burn Dressing in a 2-Year-Old Child European J Pediatr Surg Rep 7:e72-e74 (2019). PMID 31681528
  • Fischer S et al. Feasibility and safety of enzymatic debridement for the prevention of operative escharotomy in circumferential deep burns of the distal upper extremity Surgery 165:1100-1105 (2019). PMID 30678870

E. 고용량 비타민 C (High-dose ascorbate)

12편

  • Tanaka H et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study Arch Surg 135:326-31 (2000). PMID 10722036
  • Sakurai M et al. Reduced resuscitation fluid volume for second-degree experimental burns with delayed initiation of vitamin C therapy (beginning 6 h after injury) J Surg Res 73:24-7 (1997). PMID 9441788
  • Tanaka H et al. Reduced resuscitation fluid volume for second-degree burns with delayed initiation of ascorbic acid therapy Arch Surg 132:158-61 (1997). PMID 9041919
  • Tanaka H et al. Hemodynamic effects of delayed initiation of antioxidant therapy (beginning two hours after burn) in extensive third-degree burns J Burn Care Rehabil 16:610-5 (1995). PMID 8582940
  • Matsuda T et al. Antioxidant therapy using high dose vitamin C: reduction of postburn resuscitation fluid volume requirements World J Surg 19:287-91 (1995). PMID 7754637
  • Tanaka H et al. How long do we need to give antioxidant therapy during resuscitation when its administration is delayed for two hours? J Burn Care Rehabil 13:567-72 (1992). PMID 1452591
  • Novoa J et al. Intravenous vitamin C in critically ill adult patients with burns: An integrative review Nutrition 134:112728 (2025). PMID 40081106
  • Soltany A et al. A scoping review of the role of ascorbic acid in modifying fluid requirements in the resuscitation phase in burn patients Ann Med Surg (Lond) 75:103460 (2022). PMID 35386786
  • Cartotto R et al. Burn State of the Science: Fluid Resuscitation J Burn Care Res 38:e596-e604 (2017). PMID 28328669
  • Buehner M et al. Oxalate Nephropathy After Continuous Infusion of High-Dose Vitamin C as an Adjunct to Burn Resuscitation J Burn Care Res 37:e374-9 (2016). PMID 25812044
  • Ghanayem H Towards evidence based emergency medicine: Best BETs from the Manchester Royal Infirmary. BET 3: Vitamin C in severe burns Emerg Med J 29:1017-8 (2012). PMID 23180299
  • Kahn SA et al. Resuscitation after severe burn injury using high-dose ascorbic acid: a retrospective review J Burn Care Res 32:110-7 (2011). PMID 21131846

F. 대사항진 (Hypermetabolism)

31편

  • AbuBaha M et al. Hypermetabolism and Lipid Alterations Postburn: A Cardiovascular Perspective Cardiovasc Ther 2026:5983391 (2026). PMID 41660577
  • Shan H et al. Optimizing nutrition and metabolism in a severely burned patient during prolonged continuous renal replacement therapy: a case report Front Nutr 12:1749501 (2025). PMID 41613929
  • Furtado T et al. The Metabolic Impact of Biodegradable Temporizing Matrix in Burn Patients: A Retrospective Analysis of Resting Energy Expenditure and Inflammation J Burn Care Res 46:1382-1391 (2025). PMID 40679419
  • Dowling S et al. Energy expenditure following biodegradable dermal matrix application in severe burn injury: A pilot study Clin Nutr ESPEN 68:71-80 (2025). PMID 40311926
  • Kingren MS et al. HOUSING TEMPERATURE ALTERS BURN-INDUCED HYPERMETABOLISM IN MICE Shock 63:118-131 (2025). PMID 39450911
  • Bieerkehazhi S et al. β-Adrenergic blockade attenuates adverse adipose tissue responses after burn J Mol Med (Berl) 102:1245-1254 (2024). PMID 39145814
  • Stanojcic M et al. Anabolic and anticatabolic agents in critical care Curr Opin Crit Care 22:325-31 (2016). PMID 27272101
  • Jeschke MG et al. Long-term persistance of the pathophysiologic response to severe burn injury PLoS One 6:e21245 (2011). PMID 21789167
  • Trifi A et al. Early administration of norepinephrine in sepsis: Multicenter randomized clinical trial (EA-NE-S-TUN) study protocol PLoS One 19:e0307407 (2024). PMID 39024364
  • Gauglitz GG et al. Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn J Clin Endocrinol Metab 94:1656-64 (2009). PMID 19240154
  • Xie XQ et al. Neuroendocrine system response modulates oxidative cellular damage in burn patients Tohoku J Exp Med 211:161-9 (2007). PMID 17287600
  • Sugiura T et al. Effects of total parenteral nutrition on endotoxin translocation and extent of the stress response in burned rats Nutrition 15:570-5 (1999). PMID 10422088
  • Fatehi-Hassanabad Z et al. Effects of L-canavanine, an inhibitor of inducible nitric oxide synthase, on endotoxin mediated shock in rats Shock 6:194-200 (1996). PMID 8885085
  • Graves TA et al. The renal effects of low-dose dopamine in thermally injured patients J Trauma 35:97-102; discussion 102-3 (1993). PMID 8331720
  • Wu SL et al. Morphological features of platelet-rich plasma on acellular vascular scaffolds Int J Surg 111:7787-7797 (2025). PMID 40674238
  • Yang Y et al. Physicochemical Changes in Biomass Chars by Thermal Oxidation or Ambient Weathering and Their Impacts on Sorption of a Hydrophobic and a Cationic Compound Environ Sci Technol 55:13072-13081 (2021). PMID 34555895
  • Walcott SM et al. Thermoregulatory costs in molting Antarctic Weddell seals: impacts of physiological and environmental conditions: Themed Issue Article: Conservation of Southern Hemisphere Mammals in a Changing World Conserv Physiol 8:coaa022 (2020). PMID 32274067
  • Speakman JR Obesity and thermoregulation Handb Clin Neurol 156:431-443 (2018). PMID 30454605
  • Geiser F et al. A burning question: what are the risks and benefits of mammalian torpor during and after fires? Conserv Physiol 6:coy057 (2018). PMID 30323932
  • Porter C et al. Uncoupled skeletal muscle mitochondria contribute to hypermetabolism in severely burned adults Am J Physiol Endocrinol Metab 307:E462-7 (2014). PMID 25074988
  • Tidswell R et al. Experimental sepsis causes SERCA2 expression in white adipose tissue but not classical browning Sci Rep (2026). PMID 42399647
  • Zhang Y et al. HSF1 inhibits smooth muscle gene program to enhance white fat browning and hypermetabolism after burn injury Sci China Life Sci 69:2788-2800 (2026). PMID 42132988
  • Gao Y et al. From selection signatures in cattle to functional validation in mice: HSPA12B negatively regulates adipose browning and thermogenesis J Anim Sci 104 (2026). PMID 41615431
  • Zhang C et al. Ccl12 coordinates immune-neural crosstalk to promote adipose sympathetic remodeling after burn trauma Cell Rep 45:116921 (2026). PMID 41610009
  • Zhang X et al. Disease-associated adipose browning: current evidence and perspectives Adipocyte 15:2610540 (2026). PMID 41498391
  • Jia Q et al. Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning Proc Natl Acad Sci U S A 122:e2515526122 (2025). PMID 41284862
  • Pearson LE et al. To each its own: Thermoregulatory strategy varies among neonatal polar phocids Comp Biochem Physiol A Mol Integr Physiol 178:59-67 (2014). PMID 25151642
  • Tzika AA et al. Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model Int J Oncol 43:886-94 (2013). PMID 23817738
  • Tzika AA et al. Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle Int J Mol Med 24:387-92 (2009). PMID 19639232
  • Cree MG et al. Human mitochondrial oxidative capacity is acutely impaired after burn trauma Am J Surg 196:234-9 (2008). PMID 18639661
  • Zhang Q et al. Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma Int J Mol Med 18:1223-9 (2006). PMID 17089030

G. 프로프라놀롤 (Propranolol)

11편

  • Chao T et al. Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children Med Sci Sports Exerc 50:427-435 (2018). PMID 29040226
  • Guillory AN et al. Oxandrolone Coadministration Does Not Alter Plasma Propranolol Concentrations in Severely Burned Pediatric Patients J Burn Care Res 38:243-250 (2017). PMID 28240622
  • Diaz EC et al. Effects of pharmacological interventions on muscle protein synthesis and breakdown in recovery from burns Burns 41:649-57 (2015). PMID 25468473
  • Pereira CT et al. Beta-blockade in burns Novartis Found Symp 280:238-48; discussion 248-51 (2007). PMID 17380798
  • Pereira C et al. Post burn muscle wasting and the effects of treatments Int J Biochem Cell Biol 37:1948-61 (2005). PMID 16109499
  • Herndon DN et al. Gene expression profiles and protein balance in skeletal muscle of burned children after beta-adrenergic blockade Am J Physiol Endocrinol Metab 285:E783-9 (2003). PMID 12812919
  • Mei-Zahav M et al. Topical Propranolol Improves Epistaxis Control in Hereditary Hemorrhagic Telangiectasia (HHT): A Randomized Double-Blind Placebo-Controlled Trial J Clin Med 9 (2020). PMID 32998220
  • Hassoun-Kheir N et al. The Effect of β-Blockers for Burn Patients on Clinical Outcomes: Systematic Review and Meta-Analysis J Intensive Care Med 36:945-953 (2021). PMID 32686565
  • Herndon D et al. Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol Ann Surg 268:431-441 (2018). PMID 30048322
  • Rivas E et al. Resting β-Adrenergic Blockade Does Not Alter Exercise Thermoregulation in Children With Burn Injury: A Randomized Control Trial J Burn Care Res 39:402-412 (2018). PMID 28661984
  • Guillory AN et al. Propranolol kinetics in plasma from severely burned adults Burns 43:1168-1174 (2017). PMID 28645713

H. 동화 요법 (Anabolic therapy)

22편

  • Lou J et al. Oxandrolone for burn patients: a systematic review and updated meta-analysis of randomized controlled trials from 2005 to 2025 World J Emerg Surg 20:75 (2025). PMID 41023744
  • Lou J et al. The efficacy and safety of androgen analog oxandrolone in improving clinical outcomes in burn patients: a systematic review and meta-analysis of randomized controlled trials Front Med (Lausanne) 12:1485474 (2025). PMID 40861228
  • Ring J et al. Oxandrolone in the Treatment of Burn Injuries: A Systematic Review and Meta-analysis J Burn Care Res 41:190-199 (2020). PMID 31504621
  • Li H et al. The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis Burns 42:717-27 (2016). PMID 26454425
  • Real DS et al. Oxandrolone use in adult burn patients. Systematic review and meta-analysis Acta Cir Bras 29 Suppl 3:68-76 (2014). PMID 25351160
  • Breederveld RS et al. Recombinant human growth hormone for treating burns and donor sites Cochrane Database Syst Rev 2014:CD008990 (2014). PMID 25222766
  • Feathers JR et al. The Use of Oxandrolone in the Management of Severe Burns: A Multi-service Survey of Burns Centres and Units Across the United Kingdom Cureus 16:e57167 (2024). PMID 38681282
  • Jalkh APC et al. Oxandrolone Efficacy in Wound Healing in Burned and Decubitus Ulcer Patients: A Systematic Review Cureus 14:e28079 (2022). PMID 36127967
  • Kopel J et al. A Reappraisal of Oxandrolone in Burn Management J Pharm Technol 38:232-238 (2022). PMID 35832568
  • Gusti NRL et al. Effects Of Oxandrolone On Lean Body Mass (Lbm) In Severe Burn Patients: A Randomized, Double Blind, Placebo-Controlled Trial Ann Burns Fire Disasters 35:55-61 (2022). PMID 35582088
  • Chen M et al. Rapid Pterygium Progression in a Child on Growth Hormone Therapy: A Case Report and Literature Review Cureus 18:e100873 (2026). PMID 41658629
  • Han J et al. Biorhythm-mimicking growth hormone patch Nat Mater 24:1283-1294 (2025). PMID 40181125
  • Cuijpers MD et al. The efficacy of therapeutic interventions on paediatric burn patients' height, weight, body composition, and muscle strength: A systematic review and meta-analysis Burns 50:1437-1455 (2024). PMID 38580580
  • Akkoç MF et al. Investigation of the relationship of growth hormone, insulin-like growth factor (IGF)-1, and IGF-binding protein-3 levels with graft viability in autograft-transplanted pediatric patients with major burns Transpl Immunol 73:101624 (2022). PMID 35577268
  • Cai W et al. TRIP13 promotes lung cancer cell growth and metastasis through AKT/mTORC1/c-Myc signaling Cancer Biomark 30:237-248 (2021). PMID 33136091
  • Xia X et al. The relationship between H19 and parameters of ovarian reserve Reprod Biol Endocrinol 18:46 (2020). PMID 32404103
  • Boulestreau J et al. Exercise and Skeletal Muscle-Derived Extracellular Vesicles: Their Cargo, Release, and Role in Metabolic Regulation J Extracell Biol 5:e70139 (2026). PMID 42116941
  • Farahat M et al. Burn-associated metabolic dysfunction: could extracellular vesicles play a role? Clin Sci (Lond) 140:698-721 (2026). PMID 41994933
  • Berger MM et al. What does "PICS" mean in major burns? Persistent critical illness or post-intensive care syndrome Burns 52:107991 (2026). PMID 41946293
  • Zhao J et al. Inhibition of CIRBP represses the proliferation and migration of vascular smooth muscle cells via inhibiting Rheb/mTORC1 axis Biochem Biophys Res Commun 725:150248 (2024). PMID 38870847
  • Van K et al. Effect of Short-Chain Fatty Acids on Inflammatory and Metabolic Function in an Obese Skeletal Muscle Cell Culture Model Nutrients 16 (2024). PMID 38398822
  • Tian S et al. Radix Salvia miltiorrhiza Ameliorates Burn Injuries by Reducing Inflammation and Promoting Wound Healing J Inflamm Res 16:4251-4263 (2023). PMID 37791115

I. 혈당 조절 (Glycaemic control)

22편

  • Zinter MS et al. Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial Am J Respir Crit Care Med 211:1463-1473 (2025). PMID 40493436
  • GBD 2019 Acute and Chronic Care Collaborators Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019 Nat Commun 16:4235 (2025). PMID 40335470
  • Bakalář B et al. Illusory movements for immobile patients with extensive burns (IMMOBILE): A randomized, controlled, cross-over trial Burns 50:107264 (2024). PMID 39327102
  • Tehrany PM et al. Risk predictions of hospital-acquired pressure injury in the intensive care unit based on a machine learning algorithm Int Wound J 20:3768-3775 (2023). PMID 37312659
  • Lou JQ et al. [A prospectively randomized controlled study of the effects of intensive insulin therapy combined with glutamine on nutritional metabolism, inflammatory response, and hemodynamics in severe burn patients] Zhonghua Shao Shang Za Zhi 37:821-830 (2021). PMID 34645147
  • Bateman RM et al. 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016 Crit Care 20:94 (2016). PMID 27885969
  • Sodade OE et al. Intravenous insulin protocol reduces time to target glucose in critically ill trauma and burn patients J Crit Care Med (Targu Mures) 12:359-367 (2026). PMID 42516160
  • He XJ et al. Promising community nursing effect on diabetic foot patients under the "six-in-one" collaborative management model Am J Transl Res 17:9759-9770 (2025). PMID 41552321
  • Ichai C et al. Cyclosporine versus placebo pretreatment of brain-dead donors and kidney graft function (Cis-A-Rein trial): a multicenter, double-blind, randomized, controlled trial Intensive Care Med 52:289-300 (2026). PMID 41504889
  • Schaschinger T et al. The Role of Glycemic Status in Adverse Outcomes Following ENT Surgery Laryngoscope 136:1020-1029 (2026). PMID 41363265
  • Chinese Burn Association, the Yangtze River Delta Integrated Diabetic Foot Alliance, and the Editorial Committee of the Chinese Journal of Burns and Wound Repair et al. Practical guidelines for the prevention and management of diabetic foot disease in China Burns Trauma 13:tkaf064 (2025). PMID 41355887
  • Yan T et al. Severe burns complicated by EDKA, CDI, and NTIS: A case report and literature review Medicine (Baltimore) 105:e47272 (2026). PMID 41559973
  • Khalaf F et al. Beyond diabetes: harnessing the power of metformin in burn care Crit Care 29:423 (2025). PMID 41057939
  • Hallman TG et al. Metformin is associated with reduced risk of mortality and morbidity in burn patients compared to insulin Burns 50:1779-1789 (2024). PMID 38981799
  • Wang L et al. Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms J Diabetes Res 2023:4388437 (2023). PMID 38020199
  • Raucci A et al. MicroRNA-34a: the bad guy in age-related vascular diseases Cell Mol Life Sci 78:7355-7378 (2021). PMID 34698884
  • Greabu M et al. Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review Int J Mol Sci 22 (2021). PMID 34575946
  • Vanderwegen E et al. Postoperative metabolic support in the ICU Best Pract Res Clin Anaesthesiol 40:132-139 (2026). PMID 42552018
  • Fu T et al. Continuous Glucose Monitoring for Adult ICU Patients: A Meta-Analysis on Its Clinical Effectiveness Biol Res Nurs:10998004261470782 (2026). PMID 42486781
  • Lalani B et al. Long-term Performance of a Dynamic Clinical Decision Support System for Intravenous Insulin Therapy: A Retrospective Cohort Study in Patients With and Without Diabetes J Diabetes Sci Technol:19322968261467050 (2026). PMID 42478936
  • Kim M et al. Continuous Glucose Monitoring and Hypoglycaemia Risk During Paediatric DKA Treatment in the PICU: A Retrospective Cohort Study Diabetes Obes Metab (2026). PMID 42421174
  • Ammar A et al. Long-Acting Insulin and Hypoglycemia in Critically Ill Patients with Diabetes: A Sensitivity Analysis J Intensive Care Med:8850666261462876 (2026). PMID 42403155

J. 조기 절제와 이식 (Early excision and grafting)

19편

  • Wang H et al. Timing of surgical excision for burn wounds: A systematic evaluation and meta-analysis comparing early and delayed excision J Int Med Res 54:3000605261458971 (2026). PMID 42343617
  • Lombardo GAG et al. The ENGAGE Protocol: Enzymatic Debridement With NexoBrid Followed by Grafting After Graded Early Excision-A Retrospective Cohort Study J Burn Care Res 47:944-949 (2026). PMID 41717791
  • Marchica P et al. Clinical outcomes of bromelain-based enzymatic debridement (NexoBrid®): evidence from the Italian National Burn Database Burns 52:107915 (2026). PMID 41707536
  • Allorto N et al. Selective Early Excision Versus a Conservative Surgical Approach. Management of Deep Burn Injury in a Resource-Restricted Setting: A Prospective, Observational Study World J Surg 50:523-528 (2026). PMID 41664426
  • Czerny-Bednarczyk K et al. Tissue engineering as a tool in a novel approach to the comprehensive treatment and management of a deeply and extensively burned patient: case report Cell Tissue Bank 27:2 (2025). PMID 41284087
  • Jeffery SLA et al. A Scoping Review of Fluorescence Imaging: A Promising New Technology for Bacterial Detection in Burn Wounds J Burn Care Res 47:315-322 (2026). PMID 40971539
  • Atiyeh B et al. Burn Wounds and Enzymatic Debridement (ED)-Past, Present, and Future J Burn Care Res 45:864-876 (2024). PMID 38586910
  • Nanni A et al. Correction to: Research Progress of Photodynamic Therapy in Wound Healing: A Literature Review J Burn Care Res 45:257 (2024). PMID 38006256
  • Janzekovic Z Once upon a time ... how west discovered east J Plast Reconstr Aesthet Surg 61:240-4 (2008). PMID 18243082
  • De Mey K et al. Does enzymatic debridement reduce the occurrence of hypertrophic scarring in intermediate depth burns? Burns 52:107819 (2026). PMID 41380209
  • Kruglikov IL et al. The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring Front Immunol 16:1701998 (2025). PMID 41246307
  • Bird CL et al. Our initial experience with rapid enzymatic debriding agent for burn eschar: Case series from an ABA verified burn center Burns Open 10 (2025). PMID 42147452
  • Aoki K et al. A Pilot Study to Evaluate the Minimally Invasive Burn Care for Small, Deep Partial-Thickness Burns of the Hands and Feet Using Enzyme Debridement and Autologous Skin Cell Spray J Clin Med 13 (2024). PMID 39768644
  • Ball S et al. Scar outcomes for conservatively managed children post burn injury: A retrospective study Int Wound J 21:e14959 (2024). PMID 38949188
  • De Decker I et al. A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial Burns Trauma 11:tkad015 (2023). PMID 37143955
  • Heard J et al. Use of Cultured Epithelial Autograft in Conjunction with Biodegradable Temporizing Matrix in Massive Burns: A Case Series J Burn Care Res 44:1434-1439 (2023). PMID 37227867
  • Archer SB et al. The use of sheet autografts to cover extensive burns in patients J Burn Care Rehabil 19:33-8 (1998). PMID 9502022
  • Munster AM et al. Cultured epidermis for the coverage of massive burn wounds. A single center experience Ann Surg 211:676-9; discussion 679-80 (1990). PMID 2357130
  • McHugh TP et al. Therapeutic efficacy of Biobrane in partial- and full-thickness thermal injury Surgery 100:661-4 (1986). PMID 3532390

K. 감염·면역마비 (Infection and immunoparalysis)

15편

  • Demling RH et al. Comparison of the postburn hyperdynamic state and changes in lung function (effect of wound bacterial content) Surgery 100:828-35 (1986). PMID 3535145
  • Heggers JP et al. Transient and resident microflora of burn unit personnel and its influence on burn wound sepsis Infect Control 3:471-4 (1982). PMID 6924647
  • Wolk K et al. Comparison of monocyte functions after LPS- or IL-10-induced reorientation: importance in clinical immunoparalysis Pathobiology 67:253-6 (1999). PMID 10725796
  • Cao K et al. Establishment of A Mouse Sepsis-Induced Immunosuppression Model By Intranasal Instillation of Bacteria J Vis Exp (2026). PMID 42371921
  • Butsch B et al. Obesity Attenuates the Association Between the Modified Five-Item Frailty Score and Mortality in Septic Surgical Patients J Surg Res 325:506-515 (2026). PMID 42361581
  • He H et al. Impact of organ dysfunction on overall survival in patients with burns ≥ 70% TBSA: A case-control study Burns 52:107941 (2026). PMID 41819651
  • Gopi P et al. Comparative Study of Swab Culture and Tissue Biopsy in Burn Wound Sepsis: A Tertiary Centre Experience Cureus 17:e99588 (2025). PMID 41556028
  • Fan JB et al. The "cytokine storm" in infection and sepsis: win the battle but lose the war Mil Med Res 12:95 (2026). PMID 41521316
  • Giamarellos-Bourboulis EJ et al. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial JAMA 335:775-786 (2026). PMID 41359996
  • Tejiram S et al. Fighting a New Front on an Old Battlefield: Examining the Development of Topical Antimicrobial Care to Control Burn Wound Sepsis J Burn Care Res 46:248-255 (2025). PMID 39288163
  • Hoogewerf CJ et al. Topical treatment for facial burns Cochrane Database Syst Rev 7:CD008058 (2020). PMID 32725896
  • Ahuja RB et al. A prospective double-blinded comparative analysis of framycetin and silver sulphadiazine as topical agents for burns: a pilot study Burns 35:672-6 (2009). PMID 19443125
  • Connor-Ballard PA Understanding and managing burn pain: Part 2 Am J Nurs 109:54-62; quiz 63 (2009). PMID 19411907
  • Neely AN et al. Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics? J Burn Care Res 30:19-29 (2009). PMID 19060725
  • Kucan JO et al. The potential benefit of 5% Sulfamylon Solution in the treatment of Acinetobacter baumannii-contaminated traumatic war wounds J Burns Wounds 4:e3 (2005). PMID 16921408

L. 화상 약동학 (Burn pharmacokinetics)

22편

  • Závorszky L et al. Impact of augmented renal clearance on piperacillin and meropenem exposure in critically ill adult burn patients: A prospective observational study Burns 52:108138 (2026). PMID 42508095
  • Gatti M et al. Pharmacokinetics-pharmacodynamics perspective to optimizing therapy with beta-lactams in critically ill patients: an update Expert Rev Anti Infect Ther 23:1215-1233 (2025). PMID 41437777
  • Lipman J et al. The long walk to a short half-life: the discovery of augmented renal clearance and its impact on antibiotic dosing J Antimicrob Chemother 80:3367-3374 (2025). PMID 41077962
  • Olivet JD et al. Pharmacokinetics of continuous infusion ceftolozane/tazobactam in two patients with extensive total body surface area burns Pharmacotherapy 45:386-392 (2025). PMID 40231834
  • Zoccali C et al. Pharmacokinetic relevance of glomerular hyperfiltration for drug dosing Clin Kidney J 16:1580-1586 (2023). PMID 37779850
  • Hill DM et al. Pharmacokinetic Analysis of Intravenous Push Cefepime in Burn Patients with Augmented Renal Clearance J Burn Care Res 45:151-157 (2024). PMID 37688528
  • Shi Y et al. Vancomycin population pharmacokinetics in patients with burns Front Med (Lausanne) 13:1829805 (2026). PMID 42440663
  • Koreeda H et al. Patient with severe burns for whom serum cystatin C-based assessment was performed due to suspected errors in serum creatinine-based renal function evaluation: a case report Eur J Hosp Pharm (2026). PMID 41571446
  • Azadi S et al. Therapeutic vancomycin monitoring: a comparative analysis of high-performance liquid chromatography and chemiluminescent microparticle immunoassay methods in liver transplant recipients Front Pharmacol 16:1516339 (2025). PMID 40529505
  • Galvidis IA et al. Therapeutic Monitoring of Vancomycin Implemented by Eremomycin ELISA Antibiotics (Basel) 13 (2024). PMID 39766523
  • Ma P et al. Prediction of vancomycin plasma concentration in elderly patients based on multi-algorithm mining combined with population pharmacokinetics Sci Rep 14:27165 (2024). PMID 39511378
  • Santos RM et al. A Multicenter, Retrospective Outcome Analysis of Vancomycin Area Under the Curve Versus Trough-Based Dosing Strategies in Patients With Burn OR Inhalational Injuries (MONITOR) J Burn Care Res 45:1383-1389 (2024). PMID 38900835
  • Skorup P et al. Estimation of Plasma Meropenem Concentrations in Patients with Severe Infections Using Ultraviolet and Visible Range Spectrophotometry: A Pilot Study Eur J Drug Metab Pharmacokinet 51:413-420 (2026). PMID 42087051
  • Hall RG 2nd et al. Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Partial- and Full-Thickness Skin Burns Pharmacotherapy 45:774-779 (2025). PMID 41212678
  • Tebano G et al. Which Are the Best Regimens of Broad-Spectrum Beta-Lactam Antibiotics in Burn Patients? A Systematic Review of Evidence from Pharmacology Studies Antibiotics (Basel) 12 (2023). PMID 38136771
  • Závorszky L et al. [Therapeutic drug monitoring of beta-lactam antibiotics in critically ill adult patients] Orv Hetil 164:1904-1911 (2023). PMID 38043089
  • Meenks SD et al. Mass Spectrometric Characterization of Flucloxacillin Binding to Serum Albumin in Hospitalized Patients With Hypoalbuminemia: An Observational Pilot Study Ther Drug Monit (2026). PMID 42417601
  • Wei XC et al. Exploratory model-based optimizing isavuconazole dosing regimens for Aspergillus spp. in adult patients according to serum albumin levels: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation Front Cell Infect Microbiol 16:1737154 (2026). PMID 42394820
  • Morales Junior R et al. What if the Aquarium is in the Intensive Care Unit? Extending the Fish Tank Model to Teach Pharmacokinetics in Critically Ill Patients Am J Pharm Educ 90:102016 (2026). PMID 42248418
  • Nix DE et al. Correction of posaconazole concentrations for hypoalbuminemia Pharmacotherapy 45:324-331 (2025). PMID 40251837
  • Webb AJ et al. Clinical Consequences of Disproportionate Free Valproate Elevation in Critically Ill Adult Patients: A Multicenter Retrospective Cohort Study Neurocrit Care 43:472-483 (2025). PMID 40133756
  • Idasiak-Piechocka I et al. Effect of hypoalbuminemia on drug pharmacokinetics Front Pharmacol 16:1546465 (2025). PMID 40051558

M. 흡입 손상 (Inhalation injury)

16편

  • Fuciños LC et al. Cardiopulmonary hemodynamic alterations during early resuscitation in burn patients with inhalation injury: do they impact prognosis? J Burn Care Res (2026). PMID 42275046
  • Ozmen BB et al. Evidence-based AI clinical decision support system for acute burn care and complex reconstruction J Plast Reconstr Aesthet Surg 116:242-253 (2026). PMID 41934058
  • Kiwan O et al. What You Need to Know About: Assessment of Burns and Initial Management Br J Hosp Med (Lond) 86:1-18 (2025). PMID 41134176
  • Echeverri C et al. Lower Extremity Compartment Syndrome Due to Capillary Leak Syndrome Following 60% Total Body Surface Area Burn Injury J Burn Care Res 47:410-413 (2026). PMID 40996144
  • Váňa V et al. Results of microbiological surveillance in patients with high-voltage eletrical injuries: A 10-year single center experience Epidemiol Mikrobiol Imunol 74:97-106 (2025). PMID 40747749
  • Kruse M et al. Characterisation of Fluid Administration in Burn Shock-A Retrospective Cohort Analysis Eur Burn J 6 (2025). PMID 40558630
  • Nguyen TNM et al. Scheduled Bronchoscopy with Nebulized Heparin and N-Acetylcysteine in Burn Patients with Inhalation Injury: A Randomized Trial Eur Burn J 7 (2026). PMID 42201099
  • Risinger WB et al. Nebulized Heparin and N-Acetylcysteine do Not Improve Outcomes of Intubated Burn Patients With Grade II or III Inhalation Injuries Am Surg 91:1392-1395 (2025). PMID 40346841
  • Hakim SM et al. Effect of early administration of inhaled heparin on outcomes of smoke inhalation injury: A randomized controlled trial Burns 51:107518 (2025). PMID 40319829
  • Rajaratnam G et al. "To BAL or not to BAL, that is the question": Variations in smoke inhalation injury guidelines from burn units and centres in England, Scotland and Wales Burns 50:107273 (2024). PMID 39353794
  • Peters RA et al. Extracorporeal Membrane Oxygenation in a Patient with Severe Inhalation Injury: Multidisciplinary Burn Team Care J Burn Care Res 45:796-800 (2024). PMID 38367208
  • Milton-Jones H et al. An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury Crit Care 27:459 (2023). PMID 38012797
  • Swafford EP et al. Inpatient Complications and Outcomes for Burn Patients Admitted with Opioid-Positive Drug Screens J Burn Care Res (2026). PMID 42550487
  • Palmer BL et al. Corneal abrasions in burn admissions: severity and geographic access factors in a retrospective cohort Proc (Bayl Univ Med Cent):1-4 (2026). PMID 42496181
  • Matheny M et al. Residential Air Pollution, Inhalation Injury, and Burn Recovery: A Burn Model System Study J Burn Care Res (2026). PMID 42476515
  • Wardhana A et al. Mortality Analysis of ICU Burn Patients in Indonesia's National Referral Hospital: A 2-Year Retrospective Study Ann Burns Fire Disasters 39:95-99 (2026). PMID 42370050

N. 염증·사이토카인·간 (Inflammation, cytokines, liver)

16편

  • Chapman CD et al. Bactericidal and anti-inflammatory activity of defined hypochlorite solution PLoS One 21:e0352576 (2026). PMID 42497178
  • Yeong EK et al. Intravenous placenta-derived mesenchymal stem cells enhance early survival as an adjunct to supportive care in severe burn: a preclinical study Stem Cell Res Ther 17 (2026). PMID 42493791
  • Ma H et al. Modulating hypertrophic scar formation by targeting endothelial transient receptor potential vanilloid-1/nuclear factor kappa-B/interleukin-6 axis to regulate angiogenesis Burns Trauma 14:tkag009 (2026). PMID 42131490
  • Yang GX et al. The Diagnostic and Prognostic Value of Procalcitonin and High-Sensitivity C-Reactive Protein in Early-Stage Burn Sepsis: A Retrospective Cohort Study J Inflamm Res 19:571738 (2026). PMID 41873329
  • Liu H et al. Characteristics and significance of blister fluid cell-free mitochondrial DNA in pediatric small area intermediate-depth burn wounds Burns 52:107780 (2026). PMID 41297227
  • Liu XY et al. Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock Front Pharmacol 16:1614159 (2025). PMID 40900826
  • Kaur S et al. Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice Clin Transl Med 11:e417 (2021). PMID 34185433
  • Bogdanovic E et al. Endoplasmic reticulum stress in adipose tissue augments lipolysis J Cell Mol Med 19:82-91 (2015). PMID 25381905
  • Hiyama Y et al. Fenofibrate does not affect burn-induced hepatic endoplasmic reticulum stress J Surg Res 185:733-9 (2013). PMID 23866789
  • Barrow RE et al. Identification of factors contributing to hepatomegaly in severely burned children Shock 24:523-8 (2005). PMID 16317382
  • Nie C et al. The blood parameters and liver function changed inconsistently among children between burns and traumatic injuries PeerJ 7:e6415 (2019). PMID 30775182
  • Korkmaz HI et al. The role of complement in the acute phase response after burns Burns 43:1390-1399 (2017). PMID 28410933
  • Li JH et al. Suppressed acute phase response to LPS-induced hepatic injury in Smad3-deficient mice Mol Immunol 46:362-5 (2009). PMID 19058853
  • Chai J et al. [Influence of escharectomy and skin grafting during early burn stage on acute-phase response in severely burned rats and its significance] Zhonghua Yi Xue Za Zhi 82:1420-3 (2002). PMID 12509927
  • Koike K et al. Recombinant human interleukin-1alpha increases serum albumin, Gc-globulin, and alpha1-antitrypsin levels in burned mice Tohoku J Exp Med 198:23-9 (2002). PMID 12498311
  • Mooser V et al. Major reduction in plasma Lp(a) levels during sepsis and burns Arterioscler Thromb Vasc Biol 20:1137-42 (2000). PMID 10764684

O. 골·성장·장기 결과 (Bone, growth, long-term outcome)

15편

  • Moolhuijsen LME et al. Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome Nat Genet 58:1040-1050 (2026). PMID 42026183
  • GBD 2023 Demographics Collaborators Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023 Lancet 406:1731-1810 (2025). PMID 41092927
  • GBD 2023 Disease and Injury and Risk Factor Collaborators Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023 Lancet 406:1873-1922 (2025). PMID 41092926
  • GBD 2021 Risk Factors Collaborators Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 Lancet 403:2162-2203 (2024). PMID 38762324
  • GBD 2021 Diseases and Injuries Collaborators Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 Lancet 403:2133-2161 (2024). PMID 38642570
  • GBD 2021 Causes of Death Collaborators Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 Lancet 403:2100-2132 (2024). PMID 38582094
  • Damme KSF et al. The cumulative impact of fine particulate matter exposure on hippocampal volume and working memory: Insights from prenatal and adolescent exposures from the ABCD study Dev Cogn Neurosci 77:101648 (2026). PMID 41352198
  • Jilani LZ et al. Treatment of paediatric subtrochanteric femoral fractures using titanium elastic nails: a single-center experience Int J Burns Trauma 15:202-209 (2025). PMID 41278380
  • McPheron M et al. Treatment of PDGFRB -Related Penttinen Syndrome With Imatinib in a Young Child Am J Med Genet C Semin Med Genet 199:176-182 (2025). PMID 40742224
  • Wang H et al. Empagliflozin-Pretreated MSC-Derived Exosomes Enhance Angiogenesis and Wound Healing via PTEN/AKT/VEGF Pathway Int J Nanomedicine 20:5119-5136 (2025). PMID 40297404
  • Hodge KM et al. Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment Sci Rep 14:18147 (2024). PMID 39103365
  • Ungureanu A et al. Functional Recovery and Emotional Burden After Burn Injury: A Quality of Life Assessment in Romanian Burn Survivors Diseases 14 (2026). PMID 42346304
  • Akter T et al. Health-Related Quality of Life in Burn Injury Victims Attending a Specialized Institution Cureus 18:e106895 (2026). PMID 42131675
  • Vigneron L et al. Effects on health-related quality of life of therapeutic exercise in burn survivors: A systematic review and meta-analyses Burns 52:107829 (2026). PMID 41447903
  • GBD 2023 Causes of Death Collaborators Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023 Lancet 406:1811-1872 (2025). PMID 41092928

P. 특수 집단·전해질 (Special populations)

21편

  • Aigner A et al. Too much or too little? Fluid resuscitation in the first 24 h after severe burns: Evaluating the Parkland formula - A retrospective analysis of adult burn patients in Austria, Germany, and Switzerland 2015-2022 Burns 51:107397 (2025). PMID 40068435
  • Shen ZA et al. [Establishment and application of the ten-fold rehydration formula for emergency resuscitation of pediatric patients after extensive burns] Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi 39:59-64 (2023). PMID 36740427
  • Allorto NL et al. A practical formula for fluid resuscitation in acute paediatric burns in a low resource setting: A pilot study Injury 54:25-28 (2023). PMID 36089555
  • Stevens JV et al. Weight-based vs body surface area-based fluid resuscitation predictions in pediatric burn patients Burns 49:120-128 (2023). PMID 35351355
  • Khan S et al. Clinical and Epidemiological Profile, Mortality, and Associated Factors Among Paediatric Burn Patients in Western Rajasthan, India Cureus 18:e111793 (2026). PMID 42534189
  • Zakaria H et al. A global contrast shortage: a descriptive study exploring IV contrast utilization and outcomes in trauma patients at a level I trauma center Eur J Trauma Emerg Surg 52 (2026). PMID 42496906
  • Lahoti GA et al. Injury mechanism patterns, mortality predictors, and resource utilization in pediatric trauma in Karachi, Pakistan: A seven-year registry study Injury 57:113514 (2026). PMID 42475931
  • Hyman SC et al. Association of invasive intracranial pressure monitoring with mortality in severe pediatric traumatic brain injury: A national ACS TQIP analysis J Pediatr Surg:163310 (2026). PMID 42468687
  • Montesinos P et al. QuANTUM-Wild: a Phase III, randomized trial of quizartinib in newly diagnosed FLT3-ITD-negative acute myeloid leukemia Future Oncol 22:1913-1924 (2026). PMID 42434847
  • Melekoğlu T et al. Acute Biochemical Muscle Damage Responses to a Single Session of Whole-Body Electromyostimulation Med Sci Sports Exerc 58:1362-1376 (2026). PMID 41839178
  • Mitsui D et al. Severe caffeine poisoning treated with intermittent hemodialysis under circulatory support Am J Emerg Med 76:270.e5-270.e7 (2024). PMID 38129271
  • Boyd AN et al. A voltage-based analysis of fluid delivery and outcomes in burn patients with electrical injuries over a 6-year period Burns 45:869-875 (2019). PMID 30935702
  • Pollanen MS The pathology of torture Forensic Sci Int 284:85-96 (2018). PMID 29367172
  • Navarrete N Severe rhabdomyolysis without renal injury associated with lightning strike J Burn Care Res 34:e209-12 (2013). PMID 22929530
  • Maghsoudi H et al. Electrical and lightning injuries J Burn Care Res 28:255-61 (2007). PMID 17351442
  • Colligan T et al. The Impact of Remoteness on the Outcomes of Children With Prenatal Drug Exposure: A Population-Based Cohort Study J Paediatr Child Health 62:1223-1234 (2026). PMID 42186151
  • Chen C et al. Critical illness outcomes of hospitalized pregnant women following a Texas abortion ban Am J Respir Crit Care Med 212:1730-1739 (2026). PMID 42149703
  • Picetti E et al. The management of severe isolated traumatic brain injury in pregnancy: A joint consensus statement from the European Association of Neurosurgical Societies (EANS) and the World Society of Emergency Surgery (WSES) Brain Spine 6:105971 (2026). PMID 42064346
  • Saiki K et al. Social Determinants of Health, Perceived Stress Scores, and Adverse Pregnancy Outcomes Am J Perinatol (2026). PMID 41946475
  • Makarious L et al. Maternal Deaths Due to Suicide, Accidental Poisoning and Undetermined Intent Within 5 Years Following Childbirth: A Population-Based Study BJOG 133:1581-1591 (2026). PMID 41914610
  • Michelle H et al. Disparities among adolescent pregnant trauma patients J Trauma Acute Care Surg (2026). PMID 41873860

Q. 영양·미량원소 (Nutrition and micronutrients)

19편

  • Yeh DD Fueling recovery: evidence-based ICU nutrition and immunonutrition strategies in 2026 Trauma Surg Acute Care Open 11:e002284 (2026). PMID 42094750
  • Qinyuan D et al. Protein nutritional support in critically ill patients: pathophysiological basis, clinical evidence, and areas of uncertainty - a narrative review Front Med (Lausanne) 13:1770345 (2026). PMID 42040590
  • Zhou S et al. Predictive Value of Inflammatory Burden Index for Sepsis in Critically Ill Patients with Extensive Burns: A Decade-Long Cohort Study J Inflamm Res 19:574776 (2026). PMID 41884165
  • Yang X et al. Constructing the early enteral nutrition management protocol for severely burned adult patients: a Delphi study BMC Nutr 12:5 (2026). PMID 41495855
  • Nikiforov MV et al. [Nutritional support in the comprehensive management of cutaneous squamous cell carcinoma in congenital epidermolysis bullosa] Vopr Pitan 94:139-150 (2025). PMID 41263358
  • Heyland DK et al. A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries N Engl J Med 387:1001-1010 (2022). PMID 36082909
  • Heyland DK et al. A RandomizEd trial of ENtERal Glutamine to minimIZE thermal injury (The RE-ENERGIZE Trial): a clinical trial protocol Scars Burn Heal 3:2059513117745241 (2017). PMID 29799545
  • Kurjatko A et al. Trace Element Supplementation in Burn Patients: Exploring the Relationship Between Burn Size and Mineral Needs J Burn Care Res 46:411-418 (2025). PMID 39269627
  • Karakus M et al. Nutritional and metabolic characteristics of critically ill patients admitted for severe toxidermia Clin Nutr 42:859-868 (2023). PMID 37086614
  • Dusapin CJ et al. Computer customization errors compromised the optimization of trace element repletion dose after major burns Clin Nutr 41:2207-2210 (2022). PMID 36081294
  • Saeg F et al. Evidence-Based Nutritional Interventions in Wound Care Plast Reconstr Surg 148:226-238 (2021). PMID 34181622
  • Żwierełło W et al. Bioelements in the treatment of burn injuries - The complex review of metabolism and supplementation (copper, selenium, zinc, iron, manganese, chromium and magnesium) J Trace Elem Med Biol 62:126616 (2020). PMID 32739827
  • Zemrani B et al. Recent insights into trace element deficiencies: causes, recognition and correction Curr Opin Gastroenterol 36:110-117 (2020). PMID 31895229
  • Guo F et al. Prospective Study on Energy Expenditure in Patients With Severe Burns JPEN J Parenter Enteral Nutr 45:146-151 (2021). PMID 32270887
  • Xi P et al. Establishment and assessment of new formulas for energy consumption estimation in adult burn patients PLoS One 9:e110409 (2014). PMID 25330180
  • Mendonça Machado N et al. Burns, metabolism and nutritional requirements Nutr Hosp 26:692-700 (2011). PMID 22470012
  • Tancheva D et al. Comparison of estimated energy requirements in severely burned patients with measurements by using indirect calorimetry Ann Burns Fire Disasters 18:16-8 (2005). PMID 21990973
  • Barton RG et al. Chemical paralysis reduces energy expenditure in patients with burns and severe respiratory failure treated with mechanical ventilation J Burn Care Rehabil 18:461-8; discussion 460 (1997). PMID 9313131
  • Pereira JL et al. [Evaluation of energy metabolism in burn patients: indirect calorimetry predictive equations] Nutr Hosp 12:147-53 (1997). PMID 9617175

R. QSP·모델링 방법론 (QSP and modelling methodology)

17편

  • Dogné JM et al. From animal testing to model-informed drug development: building on ICH M15 and EMA initiatives to make new approach methodologies (NAMs) deliver Front Pharmacol 17:1877947 (2026). PMID 42499501
  • GBD 2023 Road Injuries Collaborators Global, regional, and national burden of road injuries 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023 Lancet Public Health (2026). PMID 42476159
  • Al-Majdoub ZM et al. Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement Br J Clin Pharmacol (2026). PMID 42449479
  • Zhang S et al. Quantitative calibration of a spatial QSP model identifies fibroblast impact on HCC immunotherapy Proc Natl Acad Sci U S A 123:e2525799123 (2026). PMID 42446991
  • Goryanin I et al. Validation of AI-enabled surrogate models in quantitative systems pharmacology: a practical, context-of-use-driven review Drug Discov Today 31:104729 (2026). PMID 42409163
  • GBD 2023 TB HIV Collaborators Global, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023 Lancet Infect Dis (2026). PMID 42385762
  • Ponthier L et al. Application of machine-learning models to predict the ganciclovir and valganciclovir exposure in children using a limited sampling strategy Antimicrob Agents Chemother 68:e0086024 (2024). PMID 39194260
  • Lu T et al. gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve CPT Pharmacometrics Syst Pharmacol 13:341-358 (2024). PMID 38082557
  • Hooijmaijers R et al. Building an adaptive dose simulation framework to aid dose and schedule selection CPT Pharmacometrics Syst Pharmacol 12:1602-1618 (2023). PMID 37574587
  • Le Louedec F et al. Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open-source R package mapbayr CPT Pharmacometrics Syst Pharmacol 10:1208-1220 (2021). PMID 34342170
  • Elmokadem A et al. Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling With mrgsolve: A Hands-On Tutorial CPT Pharmacometrics Syst Pharmacol 8:883-893 (2019). PMID 31652028
  • Elgjo GI et al. Burn resuscitation with two doses of 4 mL/kg hypertonic saline dextran provides sustained fluid sparing: a 48-hour prospective study in conscious sheep J Trauma 49:251-63; discussion 263-5 (2000). PMID 10963536
  • Zhao J et al. Integration of CTA Run-off Score and Systemic Resuscitation Indices to Predict Outcomes in Emergency Lower Extremity Flap Reconstruction: A Retrospective Cohort Study Ann Ital Chir 97:920-931 (2026). PMID 42136165
  • Hassine NBEH et al. Early Prediction of Acute Respiratory Distress Syndrome in Critically Ill Polytrauma Patients Using Balanced Random Forest ML: A Retrospective Cohort Study J Clin Med 14 (2025). PMID 41464836
  • Li K et al. Human intention recognition for trauma resuscitation: An interpretable deep learning approach for medical process data J Biomed Inform 161:104767 (2025). PMID 39746431
  • Bosma KJ et al. Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial Trials 25:855 (2024). PMID 39736673
  • Cartotto R et al. American Burn Association Clinical Practice Guidelines on Burn Shock Resuscitation J Burn Care Res 45:565-589 (2024). PMID 38051821

부록 A — 모델의 각 구성요소가 어느 절에 걸려 있는가

모델 구성요소 파일 내 위치 근거 절
Landis–Pappenheimer 교질삼투압 식 landis_pappenheimer() / R의 LP() B
Starling 식 (구역별 Kf·sigma·Pc·Pi) derive()의 Jvb·Jvu B
화상 조직의 음압 (imbibition) IMB0, TAUIMB B
관류 제한 (전달 상한·no-reflow) Jvb_cap, STASIS0, QPB0 B
림프 환류의 포화 lymph(), LBASE, LMAX, KL B
소생술 폐루프 제어기 RSTATE ODE, GCTRL, DRMAX, TAUUO C
수액 크립 · in:out 비 시나리오 creep_uncapped C
오피오이드 크립 KOPI C
콜로이드가 f_ret를 복원 FCOL, ALBSTART C
복강내압 · 복부구획증후군 IAPK·IAPB·IAPQ D
아스코르브산의 Kf 작용 EMAXVIT, KROSKF E
대사항진 (A_open 구동) REE ODE, EMAXHM, A50, HILLA F
증발 열손실 KEVAP F
프로프라놀롤 (전달자 차단) prBlock, EC50PR, KSPR G
옥산드롤론 (합성 항) oxEff, EMAXOX H
인슐린 · 혈당 · 저혈당 노출 GLC/INS/HYPOH ODE, GFEED I
조기 절제 · 이식 · 공여부 제약 apply_events(), DONPOOLF, MESH J
정량 세균학 역치 · 면역마비 BWD/HLADR/BSYS ODE K
증가된 신클리어런스 · 반코마이신 arc, CLVC, VVC L
흡입 손상의 수액 배수 · 위험 배수 INH, HZINH M
IL-6 · 음성 급성기 단백 IL6 ODE, albSyn N
골 · 성장 BMC ODE, KBONE O
소아 · 고령 · 임신 · 전기 화상 build(..., WT/AGE/TBSA/INH) P
조기 경장영양 · 글루타민 sc["nutrition"], GFEED, TFEED Q
QSP 방법론 · mrgsolve 모델 전체 R

부록 B — 이 목록을 재현하는 방법

curl -s "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed\
&retmode=json&retmax=6&term=Parkland+formula+burn+resuscitation+volume"

각 절에 해당하는 검색어를 위와 같이 질의한 뒤 esummary.fcgi로 서지사항을 받아 그대로 옮겼습니다. 중복 PMID는 최초로 등장한 절에만 남겼습니다.

⚠️ 면책 (Disclaimer)

본 문헌 목록은 모델의 가정과 파라미터가 어디에서 왔는지를 추적 가능하게 만들기 위한 것이며 임상 진료 지침이 아닙니다. 개별 논문의 결론과 모델 구현이 일치하지 않는 지점은 위 표와 README.md의 "모델이 틀리는 곳" 절에 명시했습니다.