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Codex guidelines for GM foods include the analysis of unintended effects

Nature Biotechnology volume 21, pages 739–741 (2003) Cite this article

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In response to the increased delivery of genetically modified (GM) foods to international markets, the Ad Hoc Intergovernmental Task Force on Food Derived from Biotechnology of the Codex Alimentarius Commission (Rome) agreed in March on principles for the human health risk analysis of GM foods1. These principles dictate a case-by-case premarket assessment that includes an evaluation of both direct and unintended effects. They state that safety assessment of GM foods needs to investigate direct health effects (toxicity), tendency to provoke allergic reactions (allergenicity), specific components thought to have nutritional or toxic properties, the stability of the inserted gene, nutritional effects associated with genetic modification and any unintended effects that could result from the gene insertion. Of particular note, the task force broadens risk assessment to encompass not only health-related effects of the food itself, but also the indirect effects of food on human health (e.g., potential health risks derived from outcrossing).

Unintended effects of the product

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References

  1. Codex Alimentarius Commission. Joint FAO/WHO Food Standard Programme. Codex Ad Hoc Intergovernmental Task Force on Foods Derived from Biotechnology (Codex, Yokohama, Japan) http://www.who.int/fsf/GMfood/codex_index.htmhttp://www.codexalimentarius.net/ccfbt4/bt03_01e.htm (11–14 March 2003).

  2. Baker, S.J. et al. Plant Pathol. 47, 401–410 (1998).

    Article  Google Scholar 

  3. Kirschmann, J.C. & Suber, R.L. Food Chem. Toxicol. 27, 555–556 (1998).

    Article  Google Scholar 

  4. Ames, B.N. & Gold, L.S. Proc. Natl. Acad. Sci. USA 87, 7772–7776 (1990).

    Article  CAS  Google Scholar 

  5. Prakash, C.S. Plant Physiol. 126, 8–15 (2001).

    Article  CAS  Google Scholar 

  6. Courtial, B. et al. Mol. Genet. Genomics 265, 32–42 (2001).

    Article  CAS  Google Scholar 

  7. Meyer, P. In Vitro Cell. Dev. Biol.-Plant 35, 29–35 (1999).

  8. Koprek, T. et al. Plant Physiol. 125, 354–1362 (2001).

    Article  Google Scholar 

  9. World Health Organization/Food and Agriculture Organization. Safety Aspects of Genetically Modified Foods of Plant Origin. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology (WHO, Geneva, Switzerland) http://www.who.int/fsf/GMfood/FAO-WHO_Consultation_report_2000.pdf (29 May–2 June 2002).

  10. World Health Organization/Food and Agriculture Organization. Safety Assessment of Foods Derived from Genetically Modified Microorganisms. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology (WHO, Geneva, Switzerland) http://www.who.int/fsf/Documents/GMMConsult_Final_.pdf (24–28 September 2001).

  11. Jank, B. & Haslberger, A.G. Trends Biotechnol. 18, 326–327 (2000).

    Article  CAS  Google Scholar 

  12. Courtial, B. et al. Mol. Genet. Genomics 265, 32–42 (2001).

    Article  CAS  Google Scholar 

  13. Novak, W. & Haslberger, A.G. Food Chem. Toxicol. 38, 473–483 (2000).

    Article  CAS  Google Scholar 

  14. Kumpatla, S.P., Teng, W., Buchholz, W.G. & Hall, T.C. Plant Physiol. 115, 361–373 (1997).

    Article  CAS  Google Scholar 

  15. Stokes, T.L., Kunkel, B.N. & Richards, E.J. Genes Dev. 16, 171–182 (2002).

    Article  CAS  Google Scholar 

  16. Meza, T.J. et al. Transgenic Res. 10, 53–67 (2002).

    Article  Google Scholar 

  17. Matzke, M.A., Aufsatz, W., Kanno, T., Mette, M.F. & Matzke, A.J. Adv. Genet. 46, 235–275 (2002).

    Article  CAS  Google Scholar 

  18. Bailey-Serres, J. Trends Plant Genet. 4, 142–148 (1999).

    Article  CAS  Google Scholar 

  19. Brundtland Report. Our Common Future (World Commission on Environment and Development, Nairobi, Kenya) http://www.uno.de/umwelt/entwicklung/rio5/brundtland/A_42_427.pdf (1987).

  20. World Health Organization/National Agency for the Protection of the Environment. Release of Genetically Modified Organisms in the Environment: Is it a Health Hazard? Report of Joint WHO/EURO-ANPA Seminar (WHO, Rome, Italy) http://www.euro.who.int/document/fos/Fin_rep.pdf (7–9 September 2000).

  21. Bt Corn Gene Flow in Mexico. Ag BioTech InfoNet, http://www.biotech-info.net/mexican_bt_flow.html, 18 November 2002.

  22. Alvarez-Morales, A. Transgenes in maize landraces in Oaxaca: official report on the extent and implications. Presented at the 7th International Symposium on the Biosafety of Genetically Modified Organisms (International Society for Biosafety Research, Beijing, China) http://www.worldbiosafety.net/paper (10–16 October 2002).

  23. Sánchez-González, J. de J. Concerns About the Effect of Transgene Introgression in Maize Landraces and Teosinte. Presented at the 7th International Symposium on the Biosafety of Genetically Modified Organisms (International Society for Biosafety Research, Beijing, China) http://www.worldbiosafety.net/paper/ (10–16 October 2002).

  24. http://www.jrc.cec.eu.int/download/ GMCrops_coexistence.pdf

  25. European Commission. GMOs: Commission addresses GM crop co-existence (EC, Brussels, Belgium) http://europa.eu.int/rapid/start/cgi/guesten.ksh?p_action.gettxt=gt&doc=IP/03/314|0|RAPID≶=EN&display=(5 March 2003).

  26. Anonymous. EDO News, Vol. 8, March 2002 (EDO, 2002) http://www.edo.org.au/edowa/

  27. Mauricio, R. Nat. Rev.Genet. 2, 370–381 (2001).

    Article  CAS  Google Scholar 

  28. Haslberger, A.G. Nat. Biotechnol. 19, 613 (2001).

    Article  CAS  Google Scholar 

  29. Barth, R. et al. Genetic engineering and organic farming (Research Institute for Organic Farming, Berlin, Germany) http://www.oeko.de/bereiche/gentech/documents/gruene_gentech_en.pdf (September 2002).

  30. Fehr, R. Epidemiology 10, 618–625 (1999).

  31. Corvalan, C., Briggs, D. & Zielhuis, G. (eds.). in Decision-Making in Environmental Health: From Evidence to Action (WHO/FuFN SPON, London/New York, 2000).

  32. Horvath, H. et al. Theor. Appl. Genet 102, 1–11 (2001).

    Article  CAS  Google Scholar 

  33. Shewmaker, C.K., Sheehy, J.A., Daley, M., Colburn, S. & Ke, D.Y. Plant J. 20, 401–412 (1999).

    Article  CAS  Google Scholar 

  34. Saxena, D. & Stotzky, G. Am. J. Botany 88, 1704–1706 (2001).

    Article  CAS  Google Scholar 

  35. Al-Kaff, N.S., Kreike, M.M., Covey, S.N., Pitcher, R. & Anthony, M. Nat. Biotechnol. 18, 995–999 (2000).

    Article  CAS  Google Scholar 

  36. Conner, A.J., Williams, M.K, Abernathy, D.J., Fletcher, P.J. & Genet, R.A. N. Z. J. Crop Hortic. Sci. 22, 361–371 (1994).

    Article  Google Scholar 

  37. Birch, A.N.E., Geoghegan, I.E., Griffiths, D.W. & McNicol, J.W. Ann. Appl. Biol. 140, 143–149 (2001).

    Article  Google Scholar 

  38. Momma, K. et al. Biosci. Biotechnol. Biochem. 63, 314–318 (1999).

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Authors and Affiliations

  1. The author is at the University of Vienna and the World Health Organization FOS Program for Food Safety, Geneva, Switzerland

    Alexander G Haslberger

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  1. Alexander G Haslberger
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Haslberger, A. Codex guidelines for GM foods include the analysis of unintended effects. Nat Biotechnol 21, 739–741 (2003). https://doi.org/10.1038/nbt0703-739

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