One of the interesting tidbits coming out of Microsoft's annual WinHEC conference this year is that Windows Server 2008 (and its accompanying service packs, natch) will be Microsoft's last 32-bit server operating system. After Windows Server 2008 launches, Microsoft plans no further releases of any other server-oriented 32-bit operating systems, though it's probably safe to assume that Vista and Server-derived OS flavors will continue to be released in a 32-bit edition for as long as Microsoft refreshes these particular products.
"Windows Server 2008 is the last 32-bit operating system that we'll produce," said Bill Laing, Microsoft's general manager for Windows Server, said during a keynote address at WinHEC today according to APC Magazine. Microsoft has not yet decided when the client version of Windows will follow suit, according to a post on the Vista blog.
Assuming that Microsoft, AMD, and Intel all keep their various compatibility layers intact, this shouldn't cause any major issues for end users. Windows Server 2003 is able to run 32-bit software from within a 64-bit OS, and x86-64 compatible processors from both AMD and Intel are also 32-bit compatible.